Correct answer = D.
<p>PEEPi (intrinsic PEEP, auto-PEEP, dynamic
     hyperinflation, breath-stacking) develops in patients with
     COPD when expiratory flow is diminished leading to incomplete
     exhalation of one breath before the next inspiration begins. 
     Therefore PEEPi will be minimized by maneuvers which either
     decrease minute ventilation (i.e. RR or TV), improve
     expiratory flow (i.e. administration of bronchodilators), or
     increase the expiratory time (i.e.  the inspiratory time by
     increasing inspiratory flow, eliminate inspiratory pause). 
     PEEPi increases work of breathing by forcing the respiratory
     muscles to generate sufficiently negative pleural pressure on
     each breath to overcome the positive alveolar PEEPi before any
     airflow will occur.  Application of extrinsic PEEP will offset
     the PEEPi and hence reduce the work of breathing.  However,
     application of extrinsic PEEP will not reduce the PEEPi
itself.