Clinical manifestations of infective endocarditis are protean since any organ can be involved.

Infective: Fever, Weight loss, anorexia, malaise, splenomegaly, leucocytosis

Vegetations: New murmurs, destruction of valve leading to insufficiency followed by hear failure

Embolic: 

• Janeway lesions (erythematous macules and papules on the palms and sole)

• Osler nodes (tender raised erythematous lesions on the finger and toe pads ) 

• Splinter hemorrhage in the nail beds

• Roth spots (Petechiae in retina with white centers)

Clubbing