Councilmann body
|
Fig 26 - APOPTOSIS: This form of cell death appeares to be the normal way cells are renewed in every tissue.The cells condense,become round or spherical,separate from other cells,fragment and are phagocytized by histiocytes.This is the way lumina develop in tubular structures, limbs are fashioned, organs re reabsorbed in the metamorphosis of larvae and tailes are lost by tadpoles.The cells become dehydrated,
and retain their organelles.There is no inflammatory reaction.In the
liver the apoptotic cells are called Councilmann bodies.(1) (2). |
"balloon cells"
|
Fig 27 - NECROSIS: Pale stained swollen,"ballooned" cells,edematous with
swollen nuclei,undergoing lytic necrosis and accompanied by
inflammatory reaction.EM shows marked dilatation of endoplasmic
reticulum. |
Coagulation necrosis
|
Fig 28 - COAGULATION NECROSIS: The cells are eosinophilic,moderatly
shroncken with angulated borders and pyknotic nuclei.The cells
are flat.The change may be reversible.Absent or mild inflammatory
reaction.Reticulin is intact.It is the result of ischemia,toxicity,
surgical artifacts.The illustration is from a case of acute passive
congestion due to acute myocardial infarct. |
Mallory bodies: H&E stain
|
Fig 29 - MALLORY BODIES: Chains of sharply defined cytoplasmic globules
mostly surrounding the nucleus in an enlarged,ballooned clear cell.
They are composed of masses of intermediate keratin filaments
from cytoskeleton Irregular in size and shape.They are demonstrable
by H&E,Mallory stains and by immunostains for keratin.By EM three
types can be recognizedz:Type I=parallel filaments;Type 2=randomly
orientd filaments;Type 3=granular material with some filaments at
periphery.Seen in hepatocytes of alcoholics and other conditions,
in bile duct eithelium and in alveolar cells in asbestosis. Not
diagnostic for any specific disease.It is postulated that the collapse
of the filaments toward the center makes the cell to expand and
undergo necrosis. |