Many acini form the parenchyma of the lobule.
The acinus is the functional unit of the liver. Obviously the
liver cells close to the terminal portal vein receive a blood
richer in oxygen and nutrients than those located near the
central vein,therefore the cells in these different zones
perform different biochemical functions. Also they respond
differently to injuries. By convention we call the area around
the central vein zone 1 (Z1), the area near the terminal portal vein zone 3 (Z3)and the area in between, zone 2 (Z2).