1. Which one of the following statements concerning sarcoidosis is FALSE?
Sarcoidosis is a granulomatous disease
Incidence is most frequent in the elderly
Skin lesions are commonly found
The etiology remains unknown
Treatment with antibiotics is not effective

2. Which one of the following statements concerning the diagnosis of sarcoidosis is TRUE?
Definitive diagnosis is based on the histology of transbronchial biopsy tissue
The diagnosis is based on serial angiotensin converting enzyme (ACE) levels
The chest radiograph is normal at the time of diagnosis in most patients
Normal pulmonary function studies exclude the diagnosis of sarcoidosis
The diagnosis is based on combined clinical, radiologic, histologic findings

3. Which one of the following statements concerning granulomatous disease is TRUE?
Granulomatous disease is characterized by acute inflammation
Granulomatous disease is defined by a specific histologic pattern
Malignant neoplasms do not cause granulomatous disease
Bacterial infections do not cause granulomatous disease
Lymph nodes containing granulomas are seldom enlarged

4. Signs and symptoms due to sarcoidosis occur LEAST often in relation to which of the following organs?
the eye
the skin
the upper gastrointestinal tract
the lungs
the heart

5. Which of the following findings is MOST often seen on chest radiographs in patients with sarcoidosis?
Normal chest radiograph
Bilateral symmetric hilar lymphadenopathy
Mediastinal lymphadenopathy with normal hila
Bilateral pleural effusions
Multiple lung masses

6. Computed tomography (CT) is accurately described by all of the following statements EXCEPT one.
CT is more sensitive than radiographs in showing interstitial lung disease
CT commonly demonstrates small lung nodules when sarcoidosis involves the lung
Sarcoidosis involving the lung on a CT study can resemble lymphangitic lung metastasis
Sarcoidosis often shows lung lesions which are distributed along the path of the bronchovascular bundles
CT seldom shows thoracic lymphadenopathy that is not visible on radiographs.

7. Which one of the following statements concerning sarcoidosis is TRUE?
The liver is seldom involved histologically
A majority of patients have spleen lesions on CT studies
Intra-abdominal and retroperitoneal lymphadenopathy are rare
Heart involvement most often causes conduction defects and arrhythmias
Sarcoidosis is not associated with fever

8. Which one of the following statements concerning sarcoidosis is FALSE?
Presentation with polyarthritis, erythema nodosum, fever, and bilateral hilar lymphadenopathy is known as Lofgren's syndrome
Sarcoidosis is characterized by an abnormal immune response which is related to T-cell lymphocytes
The disease is often first discovered because of an abnormal chest radiograph in a patient with few or no symptoms despite widespread radiographic lesions
Sarcoidosis can cause osteolytic bone lesions, most often in the hands and feet and most often in patients who have chronic skin lesions
Sarcoidosis affects the reticuloendothelial system including lymph nodes, the liver and the spleen, but not the bone marrow

9. One of the following statements regarding lymphadenopathy in sarcoidosis is FALSE?
Lymphadenopathy is the most common abnormal finding on chest radiographs
There are often palpable neck or peripheral lymph nodes on physical examination
Enlarged intra-abdominal and retroperitoneal lymph nodes are rare
Enlarged lymph nodes usually regress spontaneously in months to years
Thoracic lymphadenopathy can closely resemble lymphoma on imaging studies

10. This is a lateral chest radiograph which shows normal hila. Which one of the following statements referring to the lettered normal anatomy is false?
A is the right pulmonary artery
B is the aortic arch
C (black arrow) points to the left upper lobe bronchus
D (white arrow) points to a pulmonary vein
E (black arrow heads) points to the posterior wall of the bronchus intermedius

11. Which one of the following statements referring to the illustration is false?
A is pointing to a Langhans type giant cell
B is pointing to an area of noncaseous necrosis
C is pointing to a rim of lymphocytes
This is a noncaseating granuloma
This histology is specific for sarcoidosis

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