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Neural Control of Breathing
Charles L. Webber, Jr., Ph.D.

Loyola University Medical Center

 

Learning Objectives: You should be able to:

Rhoades & Tanner Text Readings: Chapter 22, Pages 401-414

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General Neural Organization

  1. Overview

     

  2. Major Components of the Respiratory System

     

  3. Cortical Influences

     

  4. Abnormal Respiratory Patterns (Fig. 33)

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Central Respiratory Controller

  1. Nucleus Tractus Solitarius (NTS, dorsomedial medulla)

     

  2. Nucleus Ambiguus (NA, ventrolateral, middle medulla)

     

  3. Nucleus Retroambigualis (NRA, ventrolateral, caudal medulla)

     

  4. Nucleus Parabrachialis Medialis (NPBM, dorsolateral pons)

     

  5. Pre-B tzinger Complex (pBOT, ventrolateral, rostral medulla)

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Mechanoreflexes and Breathing

  1. Vagal reflexes from the lungs

     

  2. Reflexes from the Upper Airways

     

  3. Spinal Cord Reflexes

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Chemoreflexes and Breathing

  1. Location of Chemoreceptors

     

  2. CO2 Response Curve (Fig. 35)

     

  3. O2 Response Curve (Fig. 36)

  4. Ventilation and Integration of Chemoreceptor Inputs

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