Susan C. Baker Ph.D.,  Microbiology & Immunology, Loyola University Chicago

 
Overview of Research

Publications

People & Projects

Coronaviruses links

Kawasaki Disease

 

 

 

 

 
Publications

Baker, S.C. and M. Denison. 2008. Cell biology of nidovirus replication complexes. In “The Nidoviruses,” (ed. S. Perlman, T. Gallagher and E.J. Snijder). ASM Press, pp. 103-113.

Baker, S.C. 2008. Coronaviridae: Molecular Biology. In “The Encyclopedia of Virology,” (ed. B. Mahy). Elsevier (in press).

Rowley, A.H., S.C. Baker,  J.M. Orenstein, S.T. Shulman.  2008.  Searching for the cause of Kawasaki Disease - cytoplasmic inclusion bodies provide new insight.  Nature Reviews Microbiology (in press). 

Bechill, J., Z. Chen, J.W. Brewer and S.C. Baker.  2008.  Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression.  J. Virol. (in press).

Clementz, M., A. Kanjanahaluethai, T.E. O’Brien, and S.C. Baker.  2008.  Mutation in murine coronavirus replicase protein nsp4 alters assembly of double membrane vesicles.  Virology (in press).

Grum-Tokars, V. K. Ratia, A. Begaye, S.C. Baker and A.D. Mesecar.  2008.  Evaluating the 3C-like protease activity of SARS-coronavirus:  Recommendations for standardized assays for drug discovery.  Virus Research 133:  63-73.

Rowley, A.H., S.C. Baker, S.T. Shulman, F.L. Garcia, L.M. Fox, I.M. Kos, S.E. Crawford, P.A. Russo, R. Hammadeh, K. Takahashi, and J. Orenstein.  2008.  RNA-containing cytoplasmic inclusion bodies in ciliated bronchial epithelium months to years after acute Kawasaki Disease.  PLoS ONE 3(2): e1582.  doi: 10.1371/journal.pone.0001582.

Devaraj, S.G., N. Wang, Z. Chen, Z.-H. Chen, M.Tseng, N. Barretto, R. Lin, C. J. Peters, C.-T. K. Tseng, S.C. Baker, and K. Li.  2007.  Regulation of IRF-3 dependent innate immunity by the papain-like protease domain of the SARS coronavirus.  J. Bio. Chem. 282: 32208-32221.

Ghosh, A.K., K. Xi, V. Grum-Tokars, X. Xu, K. Ratia, W. Fu, K. V. Houser, S.C. Baker, M.E. Johnson, and A.D. Mesecar.  2007.  Structure-based design and synthesis and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Bioorg. Med. Chem. Let. 17: 5876-5880.

Grum-Tokars, V., Ratia,  K., Begaye, A., Baker, S.C., Mesecar AD. 2007. Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery. Virus Res. Mar 28; [Epub ahead of print] 

Chen, Z., Wang, Y., Ratia, K., Mesecar, A.D., Wilkinson, K. D., Baker, S.C. 2007. Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. J. Virol. 81: 6007-18. 

Kanjanahaluethai, A., Chen, Z., Jukneliene, D., Baker, S. C. 2007. Membrane topology of murine coronavirus replicase nonstructural protein 3. Virology 361:391-401.

Snyder, E.E., Kampanya, N, ,et al. PATRIC: the VBI PathoSystems Resource Integration Center. Nucleic Acids Res. 2007 Jan;35(Database issue):D401-6. 

Ghosh, A.K., K. Xi, M.E. Johnson, S.C. Baker, and A.D. Mesecar. 2006. Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy. Annual Reports in Medicinal Chemistry, Vol 41: 183-196.

Snyder, E.E., N. Kampanya et al., 2007. PATRIC: The VBI PathoSystems Resource Integration Center. Nucleic Acids Res. 35: 401-406. 

Ratia, K., K.S. Saikatendu, B.D. Santarsiero, N. Barretto, S.C. Baker, R.C. Stevens, and A.D. Mesecar.  2006.  SARS coronavirus papain-like protease:  structure of a viral deubiquitinating enzyme.  Proc. Natl. Acad. Sci.  103:  5717-5722.

Baker, S. C., D. Jukneliene, A. Purkayastha, E. E. Snyder, O. R. Crast, M. J. Czar, J. C. Setubal and B. W. Sobral.  2006.  Developing bioinformatics resources for coronavirus.  Adv. Exp. Med. 581: 395-398.

Baker, S. C., C. Shimizu, H. Shike, F. Garcia, L. van der Hoek, T. W. Kuijper, S. L. Reed, A. H. Rowley, S. T. Shulman, H. K. B. Talbot, J. V. Williams, and J. C. Burns.  2006.  Human coronavirus NL63 infection is not associated with acute Kawasaki disease.  Adv. Exp. Med. 581:  523-526.

Barretto, N., D. Jukneliene, K. Ratia, Z. Chen, A. D. Mesecar, and S. C. Baker.  2006.  Deubiquitinating activity of the SARS-CoV papain-like protease.  Adv. Exp. Med.581:  37-41.

Bechill, J., Z. Chen, J. W. Brewer, S. C. Baker.  2006.  Mouse hepatitis virus infection activates the IRE1/XBP1 pathway of the unfolded protein response.  Adv. Exp. Med. 581: 139-144. 

Rowley, A. H.,  S.T. Shulman, F. L. Garcia, J. A. Guzman-Conttrill, M. Miura, H. L. Lee, and S. C. Baker.  2005.  Cloning the arterial IgA antibody response during acute Kawasaki disease.  J. Immunol. 175: 8386-8391.

Barretto, N., D. Jukneliene, K. Ratia, Z. Chen, A. D. Mesecar and S. C. Baker.  2005.  The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.  J. Virol. 79: 15189-15198 (selected for JVI Spotlight).

Ghosh, A. K., K. Xi, K. Ratia, W. Fu, B. H. Harcourt, P. A. Rota, S. C. Baker, M. E. Johnson and A. D. Mesecar.  2005.  Design and synthesis of peptidomimetic Severe Acute Respiratory Syndrome chymotrypsin-like protease inhibitors.  J. Med. Chem. 48: 6767-6771.

Rowley, A.H., S.C. Baker, S.T. Shulman, L. Fox, K. Takahasi, F.L. Garcia, S.E. Crawford, P. Chou, and J.M. Orenstein.  2005.  Cytoplasmic inclusion bodies are detected by synthetic antibody in ciliated bronchial epithelium during acute Kawasaki Disease.  J. Infec. Dis 192: 1757-1766.

Shimizu, C., H. Shike, S.C. Baker, F. Garcia, L. van der Hoek, T. W. Kuijpers, S.L. Reed, A. H. Rowley, S. T. Shulman, H.K.B. Talbot, J. V. Williams, and J.C. Burns.  2005.  Human coronavirus NL63 is not detected in the respiratory tract of children with acute Kawasaki disease.  J. Infec. Dis. 192: 1767-1771.

Harcourt, B. H., D. Jukneliene, A. Kanjanahaluethai, J. Bechill, K. M. Severson, C. M. Smith, P.A. Rota and S. C. Baker.  2004.  Identification of SARS coronavirus replicase products and characterization of papain-like protease activity.  J. Virol. 78: 13600-1612.

S. C. Baker. 2004. Coronaviruses:  From Common Colds to SARS. Concise Reviews, Pediatric Infectious Disease Journal 23:  1049-1050.  (invited review).

Rowley, A. H., S. C. Baker, S. T. Shulman, F. L. Garcia, J. A. Guzman-Cottrill, P. Chou, M. Terai, T. Kawasaki, M. B. Kalelkar, and S. E. Crawford.  2004.  Detection of antigen in bronchial epithelium and macrophages in acute Kawasaki Disease by use of synthetic antibody.  J. Infec. Dis. 190: 856-865.

Kanjanahaluethai, A. and S. C. Baker.  2004.  Coronavirus papain-like endopeptidases, pp. 1265-1269.  In "Handbook of Proteolytic Enzymes," Second Edition, A. Barratt et al., Eds.  Academic Press.  (invited review).

Kanjanahaluethai, A., Jukneliene, D. and S. C. Baker.  2003.  Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2.  J. Virol. 77: 7376-7382.

Kanjanahaluethai, A. and S. C. Baker.  2003.  Generating the coronavirus RNA replication complex:  Proteolytic processing and membrane association.  In “RNA viruses:  Mechanisms of replication and transcription,”  X. Zhang, Ed.  Research Signpost.  (invited review).

Gosert, R., A. Kanjanahaluethai, D. Egger, K. Bienz, and S. C. Baker.  2002.  RNA replication of mouse hepatitis virus takes place at double-membrane vesicles.  J. Virol. 76:  3697-3708.

Rowley, A. H., S. T. Shulman, B. T. Spike, C. A. Mask, and S. C. Baker.  2001.  Oligoclonal IgA response in the vascular wall in acute Kawasaki Disease.  J. Immunol. 166: 1334-1343.

Gosert, R., A. Kanjanahaluethai, D. Egger, K. Bienz and S.C. Baker.  2001.  Comparison of replicase localization in different types of mouse hepatitis virus (MHV)-infected cells. Adv. Exp. Med. 494:  275-281.

Kanjanahaluethai, A. and S. C. Baker.  2001.  Processing of the replicase of murine coronavirus: Papain-like proteinase 2 (PLP2) acts to generate p150 and p44.  Adv. Exp. Med. 494:  267- 273.

Baker, S. C., A. Kanjanahaluethai, N. M. Sherer, D. D. Axtell, and J. J. Schiller.  2001.  Exploiting DNA immunization to generate polyclonal antisera to coronavirus replicase proteins. Adv. Exp. Med. 494:  283-289.

Kanjanahaluethai, A. and S. C. Baker.  2000.  Identification of mouse hepatitis virus papain-like proteinase 2 activity.  J. Virol. 74: 7911-7921.

Rowley, A. H., S. T. Shulman, C. A. Mask, L. Finn, M. Terai, S. C. Baker, C. A. Galliani, K. Takahashi, S. Naoe, M. Kalelkar and S. E. Crawford.  2000.  IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney and coronary artery in acute Kawasaki Disease.  J. Infect. Dis. 20: 1183-1191.

Shi, S. T., J .J. Schiller, A. Kanjanahaleuthai, S. C. Baker, J-W. Oh, and M.M.C. Lai.  1999. Colocalization and membrane association of murine hepatitis virus gene 1 products and de novo synthesized viral RNA in infected cells.  J. Virol. 73: 5957-5969.

Schiller, J. J. and S. C. Baker.  1998.  Coronavirus papain-like endopeptidase.  In "Handbook of Proteolytic Enzymes,"  A. Barratt et al., Eds.  Academic Press. (invited review).

Schiller, J. J., A. Kanjanahaleuthai, and S. C. Baker.  1998.  Processing of the coronavirus MHV-JHM polymerase polyprotein:  Identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a.  Virology 242:  288-302.

Schiller, J.J. and S.C. Baker.  1998.  Maturation of the polymerase polyprotein of the coronavirus MHV strain JHM involves a cascade of proteolytic processing events.  Adv. Exp. Med.  440:  135-139.

Rowe, C. L., S. C. Baker, M. J. Nathan, J.-Y. Sgro, A. Palmenburg and J. O. Fleming.  1998.  Evolution of the MHV quasispecies during persistent infection.  Adv. Exp. Med. 440: 759-765.

Rowley, A. H., C. A. Eckerley, H. M. Jack, S. T. Shulman, and S. C. Baker.  1997.  IgA plasma cells in vascular tissue of patients with Kawasaki Syndrome.  J. Immun. 159:  5946-5955.

Rowe, C. L., J. O. Fleming, J.Y. Sgro, A. Palmenburg, and S. C. Baker.  1997.  Generation of coronavirus spike deletion variants (SDVs) by high frequency recombination at regions of predicted RNA secondary structure.  J. Virol.  71:  6183-6190.

Rowe, C. L., S. C. Baker, M. J. Nathans and J. O. Fleming.  1997.  Evolution of mouse hepatitis virus:  Detection and characterization of spike deletion variants (SDVs) during persistent infection.  J. Virol  71:  2959-2969.

Gao, H.-Q., J. J. Schiller and S. C. Baker.  1996.  Identification of polymerase polyprotein products, p72 and p65, of murine coronavirus.  Virus Res. 45:  101-109.

Adami, C., J. Pooley, J. Glomb, E. Stecker, F. Fazal, J. O. Fleming, and S. C. Baker. 1995.  Evolution of mouse hepatitis virus (MHV) during chronic infection:  Quasispecies nature of the persisting MHV RNA.  Virology 209:  337-346.

Dong, S., H.-Q. Gao and S.C. Baker.  1995. Proteolotic processing of the MHV polymerase polyprotein:  Identification of the p28 cleavage site and the adjacent protein, p65.  Adv. Exp. Med. 380:  431-435.

Fleming, J.O., C. Adami, J. Pooley, J. Glomb, E. Stecker, F. Fazal, and S.C. Baker. 1995.  Mutations associated with viral sequences isolated from mice persistently infected  with MHV-JHM.  Adv. Exp. Med. 380:  591-595.

Rowley, A.H., C.L. Rowe,C. A. Eckerley, and S.C. Baker.  1995.  Isolation of novel cDNAs from the serum of patients with Kawasaki Syndrome.  In “Kawasaki Disease,” pp. 187-192.  H. Kato, editor.  Elsevier Science Press.

Dong, S. and S. C. Baker.  1994.  Determinants of the p28 cleavage site recognized by the first papain-like cysteine proteinase of murine coronavirus.  Virology 204: 541-549.

Baker, S. C., K. Yokomori, S. Dong, R. Carlisle, A. E. Gorbalenya, E. V. Koonin and M. M. C. Lai.  1993.  Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus.  J. Virol. 67:  6065-6063.

Fleming, J. O., J. J. Houtman, H. Alaca, H. C. Hinze, D. McKenzie, J. Aiken, T. Bleasdale, and S. C. Baker.  1993.  Persistence of viral RNA in the central nervous system of mice inoculated with MHV-4.  Adv. Exp. Med. 342: 327-332.

S. C. Baker, H.-Q. Gao, and R. S. Baric.  1993.  Altered proteolytic processing of the polymerase polyprotein in RNA(-) temperature sensitive mutants of murine coronavirus.  Adv. Exp. Med. 342: 215-220.

Yokomori, K., S. C. Baker , S. A. Stohlman and M. M. C. Lai.  1992.  Hemagglutinin-esterase-specific monoclonal antibodies alter the neuropathogenicity of mouse hepatitis virus.  J. Virol.  66:  2865-2874.

Baker, S. C. and M. M. C. Lai.  1990.  An in vitro system for the leader-primed transcription of coronavirus mRNAs.  EMBO J. 9:  4173-4179.

Lin, J.-H., M.-F. Chang, S. C. Baker, S. Govindarajan and M. M. C. Lai.  1990.  Characterization of hepatitis delta antigen: specific binding to hepatitis delta virus RNA.  J. Virology 64:  4051-4058.

Moyer, S. A., S. C. Baker and S.M. Horikami.  1990.  Host cell proteins required for measles virus reproduction.  J. Gen. Virol.  71:  775-783.

Baker, S. C., N. La Monica, C.-K. Shieh and M. M. C. Lai.  1990.  Murine coronavirus gene 1 contains an autoproteolytic activity.  Adv. Exp. Med. 276:283-289.

Baker, S. C., C.-K. Shieh, L. H. Soe, M.-F. Chang, D. M. Vannier and M. M. C. Lai.  1989.  Identification of a domain required for the autoproteolytic activity of murine coronavirus gene A polyprotein.  J. Virol. 63:  3693-3699

Makino, S., C.-K. Shieh, L. H. Soe, S. C. Baker  and M. M. C. Lai.  1988.  Primary structure and translation of a defective interfering RNA of murine coronavirus.  Virology.  166:  550-560.

Chang, M.-F., S. C. Baker, L. H. Soe, T. Kamahora, J. G. Keck, S. Makino, S. Govindarajan and M. M. C. Lai.  1988.  Human Hepatitis Delta antigen is a nuclear phosphoprotein with RNA-binding activity.  J. Virol. 62:  2403-2410.

Baker, S. C. and S. A. Moyer.  1988.  Encapsidation of Sendai virus genome RNAs by purified NP protein during in vitro replication.  J. Virol. 62:  834-838.

Soe, L. H., C.-K. Shieh, S. C. Baker, M.-F. Chang and M. M. C. Lai.  1987.   Sequence and translation of the murine coronavirus 5'-end genomic RNA reveals the N-terminal structure of the putative RNA polymerase.  J. Virol. 61:  3968-3976.

Baker, S. C. and S. A. Moyer.  1987.  Tubulin is a transcription factor for the negative stranded Sendai and vesicular stomatitis viruses.  In "The Biology of Negative Strand Viruses,"  pp.141-149.  Elsevier Science Publishers,  New York.

Moyer, S. A., S. C. Baker and J. L. Lessard.  1986.  Tubulin :  A factor necessary for the synthesis of both Sendai virus and vesicular stomatitis virus RNAs.  Proc. Natl. Acad. Sci. 83:  5405-5409.

Carlsen, S. R., R. W. Peluso and S. A. Moyer.  1985.  In vitro replication of Sendai virus wild-type and defective interfering particle genome RNAs.  J. Virol. 54:  493-500.