John Clancy, Jr., Ph.D.

Ph.D., University of Iowa

Cytokines in transplantation and tumor Immunology

Graft-versus-host disease (GVHD), cytokines, T cells, heat shock proteins, neuroimmunology, serotonin



Potentially lethal graft-versus-host disease (GVHD) occurs when foreign immunocompetent cells are transfused into immunocompromised recipients. GVHD is a frequent occurrence after human bone marrow transplantation for leukemia or aplastic anemia. While the putative donor effectors have been shown to be T cells, other recruited donor as well as host cell types may also be involved. As a result of such donor and host cell interactions, a cascade of immunoreactive cytokines ensues which causes severe pathologic lesions in host skin, liver, gut, lung as well as lymphoid tissue. Studies in my laboratory are designed to understand the source (phenotype and genotype), target organ compartments affected and mechanistic consequences of such a cytokine cascade in order to control and hopefully counteract it. Such studies will not only help us understand the mechanisms of immunopathology in GVHD but also some of the mechanisms of organ transplant rejection and autoimmune disease.

Studies are also in progress designed to elucidate the mechanism of serotonin enhancement of the immune system. These and other studies should help to further understanding of interactions between the nervous and immune systems.

Selected Publications

Goral, J., H.L. Mathews and J. Clancy, Jr. Antibodies specific for the 70-kD heat shock protein parallel the development of acute graft-versus-host disease in (DAXL)F1 rats. Clinical Immunology and Immunopathology, 75: 147-153, 1995

Workman, D. and J. Clancy, Jr. Phenotypes of lung infiltrating cells during acute lethal graft-versus-host disease. American J. of Pathology, 147: 1350-1360, 1995

Clancy, J. Jr. and S. Lorens Subchronic and chronic exposure to d-Fenfleuramine dose-dependently enhances splenic immune functions in young and old male Fisher-344 rats. Behavioral Brain Research, 73: 355-358, 1996.



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