Bladder Cancer
  • University of Southern California - Multicenter Trial of Adjuvant Chemotherapy in Organ-Confined Bladder Cancer Based on p53 Status

Patients undergoing cystectomy for bladder cancer are serum tested for abnormalities in the p53 gene. Patients demonstrating abnormal p53 genes are randomized to either chemotherapy or observation following cystectomy. Patients with normal p53 genes are observed. Recurrence and survival of the three groups is compared.

  • Ilex/NCI - Phase III Randomized, Double-Blind Study of DFMO versus Placebo in Low Grade Superficial Bladder Cancer

Patients with either newly diagnosed or recurrent bladder cancer will be randomized to either DFMO or placebo following resection of the tumor.