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Newsletter
- Spring 2007
Welcome to the Department of Surgery Newsletter. We hope you find this information helpful.
From Where l Sit............
Richard L. Gamelli, MD, FACS
The signs of spring are all around us here in Chicago.
The
surest of these is the opening of the baseball season. The Sox have their
home opener on April 2 and all of the southsiders have visions of another
World Series. We are all trying to forget last year's finish. For our
department, similar sentiments abound. The match went very well for
students applying in surgery as it did for our surgical residency. Three of
our own Loyola students matched into our six categorical slots. They along
with the three outside candidates that we were successful in matching with
give us an excellent entering class of surgical residents. Five of our six
chief residents have secured fellowship positions for the coming year and
one is awaiting the plastic surgical match. With all six of our chief
residents slotted to go onto fellowships, it has truly been an excellent
year for our department and its surgical training program. To add to this,
two of current surgical residents will receive the PhD at the spring
graduation. Things continue to change dramatically here on campus. The
skeleton of the addition to the main hospital is pretty much in place.
Within two years there will be nine new operating rooms and 64 more beds.
This represents the first real upgrade to the inpatient facility since the
1980’s when the Russo pavilion and tower that Dr. Freeark spearheaded was
built. It will give this department a great opportunity to expand its
services and add new faculty. Our plans for growth are well underway. We
are in an active recruiting phase for faculty in Trauma and Critical Care,
Peripheral Vascular Surgery and Pediatric Surgery. We are also expanding
our Research Division with a firm commitment from the school of medicine
under the leadership of Dean Lee to add three more positions in surgical
research within the Burn and Shock Trauma Institute. Each of these
opportunities brings new challenges and a fair amount of work to get the
right fit. We also have new leadership at the helm of the Medical Center
with Dr. Paul Whelton having succeeded Dr. Anthony Barbato. Tony had been
the leader of this medical campus for the last few decades. We are all
learning a new style of leadership, but one that is directed at continuing
to move us forward. This provides another level of opportunity as well as
excitement as we go into this new academic year. One thing that is certain
about an academic medical center, particularly our own, is that the one
constant is change. With the change of leadership and the passing of Dr.
Freeark who had served as Chair of this Department for twenty five years, we
recognize that the responsibility squarely rests with us to improve and
grow. We are going about doing just that, and this department looks forward
to another year of growth and building our people and programs.
Feature
Articles
Call for Nominations
for “The Juan Angelats, MD Service Award”
In the
Fall 2006 Department of Surgery Newsletter, Dr. Gamelli announced the
establishment of the “The Juan Angelats, MD Service Award.” We are now
seeking nominations for this prestigious award.
Letters calling for nominations for “The Juan Angelats, MD Service Award”
were mailed on March 15, 2007 to Department of Surgery faculty, staff,
alumni, fellows, residents, and emeritus faculty.
The
award is open to Department of Surgery faculty, staff, alumni, fellows,
residents, and emeritus faculty that have demonstrated a patterned long-term
behavior of service.
The
goal is to announce the recipient of this year’s award at the
Department’s annual farewell and welcome dinner in June. All nominees must be
submitted by Friday, May 4, 2007, to allow the selection committee ample time
to review all submissions.
Should you have any questions
regarding this prestigious award and the nomination process, please feel free to
contact: Tim O’Hern (708)327-2707, email:
tohern@lumc.edu, or Karen Pyrz (708)327-2679 email:
kpyrz@lumc.edu
Resident
Project Service
Award
In addition to the establishment
of the Juan Angelats Service Award, a second award was announced in the
Department of Surgery Fall 2006 Newsletter, the “Resident Service Project Award.”
Emails went out on March 13, 2007 to all current residents and fellows calling
for proposals for this prestigious award. The recipient of this year’s award
will be announced at our annual farewell and welcome dinner in June. This is a
unique and exciting opportunity for residents to develop a project that will
enhance their clinical experience, and give back to the underserved social
community. The award is open to all current residents
and fellows in good standing.
Should you have any questions
regarding this award, please feel free to contact Kim Echert, (708) 327-2335 or
email:
kechert@lumc.edu
Clinical
Spotlight
Intra-Abdominal Organ Transplantation Building
Referrals and Growth
John J. Brems, M.D.
When John J. Brems, M.D. first
came to Loyola University Health System (LUHS) in 1997, his main job was to
build a hepatobiliary program that included liver transplantation. Since then
almost 200 liver transplants have been performed. “We are very proud of the
entire multidisciplinary team responsible for liver transplantation and the
commitment of the institution to the program,” explained Dr. Brems, who is the
director of Intra-Abdominal Organ Transplantation at LUHS.
Of particular note are the
survival statistics for LUHS liver transplant patients, the latest tabulated
from July 2003 through December 2005. The one-year survival rate is 90 percent
and 86 percent for three-year survival, rates that match or exceed national
averages as determined by United Network for Organ Sharing, according to Dr.
Brems.
Happy with the results to date,
Dr. Brems is working to build the program further and to establish LUHS as the
liver transplantation center of choice in the western suburbs of Chicago. “We
have a great team of anesthesiologists, hepatologists, nurses and coordinators
so the whole framework is in place,” he added.
“Patients require liver
transplants due to end-stage liver disease,” said Dr. Brems, who is the John P.
Igini, M.D., Professor of Surgery in the Department of Surgery of Loyola
University Chicago Stritch School of Medicine.
“Hepatitis C is the indication
for liver transplantation,” he noted. Most patients are unaware that they have
been infected with hepatitis C, since it often has no symptoms other than
fatigue. Some of these patients, who were infected before the blood supply was
screened for the virus in 1990, may later develop end-stage liver disease.
“Hepatitis C has reached epidemic proportions in the population,” Dr. Brems
said.
He also has seen a “tremendous
increase” in patients with primary and secondary liver carcinomas that require a
liver resection. Sixty percent of patients with colon cancer will develop liver
metastases, which are treated with a liver resection.
Dr. Brems and his team are
setting up a multidisciplinary clinic for patients with primary liver tumors, a
group that presents a challenge since chemotherapy is not a treatment option.
“These patients now can receive the best care possible from a seasoned team of
hepatologists, surgeons and radiation oncologists,” he added. Using the latest
research tools, Dr. Brems is exploring new ways to treat liver tumors more
effectively.
He also is investigating how to
increase the number of liver organs available for transplantation. “Currently,
about 15-20 percent of our patients die before they receive a transplant,” Dr.
Brems said. Now transplant surgeons are widening the pool of potential donors,
by re-considering those labeled “marginal donors” in the past, such as people
with “fatty livers,” as well as otherwise healthy older donors in the 60-85 age
range, since livers are thought to be among the hardiest of the body’s organs.
Another group of non-traditional liver donors may include those who have
suffered cardiac death. Dr. Brems is studying how ischemic reperfusion may
revitalize these livers with no ill effects.
For more information about
Intra-Abdominal Organ Transplantation, please call (708) 327-2539.
Loyola
Abdominal Transplant Program Striving for ‘Bigger
and Better’
David R. Holt, M.D., F.A.C.S.
Since he came to Loyola University
Health System (LUHS) in 1998,
David R. Holt, M.D., F.A.C.S., has played a major
role in Intra-Abdominal Organ Transplantation.
As a vital member of the liver
transplantation team, and director of kidney transplantation, he has played a
key role in the development and growth of the liver and kidney transplant
programs. The kidney transplant waiting list has nearly doubled in the last 5
years, going from 350 to 600. As a result, LUHS now has the third largest kidney
transplant waiting list in Illinois, according to Dr. Holt, who is associate
professor of surgery in the Department of Surgery of Loyola University Chicago
Stritch School of Medicine. Since its inception in 1997, almost 200 liver
transplants have been performed and from 1988 through 2006, 988 patients have
undergone kidney transplants at LUHS.
Working to improve the lives of
his transplant patients, Dr. Holt currently is involved in clinical trials of
novel immunosuppressant drugs and regimens. He cites the new, more effective
drugs as improving the survival and quality of life for transplant patients over
the years. Other efforts have been used to increase the number of patients
transplanted including the use of expanded criteria donors, a trend shared by
kidney, liver, heart, and lung transplant programs. “As more people have been
listed for transplantation, we have become more aggressive in using organs that
were not considered in the past, creating more opportunities for
transplantation,” Dr. Holt explained.
Pushing the boundaries of what’s
possible is part of Dr. Holt’s history. As a transplant fellow at Johns Hopkins
Hospital, in Baltimore, MD, he was part of the team that first performed
laparoscopic donor nephrectomies. This minimally invasive technique has resulted
in less pain and shorter recovery times for kidney donors and can also be an
incentive for people to donate a kidney. In the future, it is possible that
this minimally invasive approach may be used for living liver donors. Dr. Holt
has already performed laparoscopic liver resections for disease, which is
relatively new in the country. In addition to liver resection he also performs
other procedures for treatment of liver tumors, such as radiofrequency
ablation.
Dr. Holt also serves as director
of undergraduate education for the Department of Surgery. In this role, he is
responsible for the clinical rotation of third- and fourth-year students of
Stritch School of Medicine. In addition, he provides training for surgery and
urology residents who rotate through the transplant unit of Loyola University
Medical Center.
Dr. Holt foresees future
alternatives to immunosuppressive drugs – currently possessing potential risks
for infection and cancer among other side effects– that will fool the immune
system into thinking a transplanted organ is part of the body. He also thinks it
is possible in the future for medical science to create organs – a liver or
pancreas for example – through stem cells or other means.
In the meantime, he is focused on
the present and it looks very positive. “We are striving for a bigger and better
program in Intra-Abdominal Organ Transplantation,” Dr. Holt added.
For more information, please call
(708) 327-2539.
Surgery In
the News
Dr. Joehl Discusses “Acid
Reflux”
Dr. Raymond J. Joehl, M.D.
Professor of Surgery, Vice Chair of Education,
Program Director, and Chief of Surgery, Hines VA Hospital was quoted in the
winter 2006 issue of the “Blue Medicare Rx Newsletter” in an article
entitled: Acid Reflux Mocks Good Manners.
Dr. Geoffrey Silver
Thanked in Local Paper
Gerry Smith, a surgical patient
of Dr. Silver, died recently. Mr. Smith wanted to write a book
about his experience at Loyola. Sadly, he died before that goal was
accomplished. His daughter, Kim Smith, felt strongly enough about her
father’s wish that she took up the mission and wrote a public letter to the
local newspapers. Ms. Smith wrote, “My father, who is the publisher at
Liberty Suburban Chicago Newspapers… often spoke of writing an article or even a
book about his recent experiences. There are a few topics and individuals he
frequently mentioned that I would like to write about.”
Ms. Smith goes on to thank four
different Loyola caregivers. “First, my father wanted to say “thank you” to
the nurses in High Dose, where he stayed during his bone marrow transplant…
Second… his oncologist, Dr. Patrick Stiff…Third, my father’s surgeon,
Dr. Silver and his
team, deserve a thank you. They have taken numerous phone calls, dealt with our
anxiety and done their very best for my father… Lastly, and most importantly,
the nurses on the fourth floor west of the ICU.”
Ms Smith wrote. “We are grateful
we had hope for the past several weeks and have not been tormented by “what ifs”
… I cannot thank these people enough and would encourage them to continue to
give their patients and their families hope.”
This touching letter illustrates
how the doctors and nurses of Loyola Medicine impact the lives of everyone they
touch. Thank you to GateHouse Media, for their permission to quote excerpts
from Ms. Smith’s letter.
Dr.
Gamelli Interviewed on Evening News
Richard L. Gamelli, M.D., F.A.C.S., Chairman, Department of
Surgery, Director; Burn & Shock Trauma Institute; Chief, Burn Center, was
interviewed on WGN news on February 14, 2007 for their series “Painful
Painkillers.” Dr. Gamelli spoke about Toxic Epidermal Necrolysis (TENS).
Announcements
Oral Health Center – New Division Chief
The Department of Surgery welcomes
Ronald L. Guttu, D.D.S., M.S.D. to the Oral Health Center. On February 1st,
Dr. Guttu joined the faculty as Professor of Surgery and Chief of Oral and
Maxillofacial Surgery and Dental Medicine. Dr. Guttu will also be the Director
of the Oral and Maxillofacial Surgery Residency Program. After almost 14 years
of service to the Department of Surgery, Mark Steinberg, D.D.S., M.D. has
resigned from these positions and will assume a part-time role in the Oral
Health Center.
Dr. Guttu received his dental degree from the
University of Washington School of Dentistry, where he also completed his Oral
Medicine Residency and received his Masters of Science in Dentistry. His Oral
and Maxillofacial Surgery training was obtained at the
University of Illinois-Chicago and at the Medical College of Virginia. He has
been board certified in Oral and Maxillofacial Surgery since 1990.
Dr. Guttu joins us from Gundersen Lutheran Medical
Center in La Crosse, Wisconsin, where he served as the Director of their Oral
and Maxillofacial Surgery Residency program since 2005. Prior to this
appointment, he spent almost one year in Norway revising the oral surgery
curriculum at the University of Bergen and establishing the first dental
anesthesia program in Norway. Before his time overseas, Dr. Guttu was in private
oral and maxillofacial surgery practice in Mount Vernon, Washington. He has also
been the co-director of a volunteer dental project in Jamaica for over 18 years.
Dr. Guttu is a member of multiple professional
societies and is also a Fellow of the American Association of Oral and
Maxillofacial Surgeons and a Fellow of the International Association of Oral and
Maxillofacial Surgeons. He has an active interest in anesthesia, pediatric oral
and maxillofacial surgery, oral pathology and reconstruction, trauma,
orthognathic surgery, dental implants and oral medicine. He is a welcome
addition to our Oral Health Center.
Department of Surgery Seeks a
Pediatric Surgeon
Loyola University Chicago, Stritch
School of Medicine, Department of Surgery is seeking a Pediatric Surgeon.
Candidates at all academic levels will be considered. A highly competitive
benefits package including institutional malpractice coverage, travel funds and
salary commensurate with experience and time in rank is available. The clinical
practice is based at the Foster G. McGaw Ronald McDonald® Children’s Hospital in
Maywood, Illinois. This 545-bed hospital is licensed for 100 pediatric beds-50
in Neonatal ICU and 50 in the Pediatric Unit which include 14 Intermediate Care
Beds and 12 ICU Beds. The Ronald McDonald® Children’s Hospital of Loyola
University Medical Center is a Pediatric Critical Care Center for Excellence as
certified by the Illinois Department of Public Health.
Loyola University Health System’s $103 million medical
center expansion is scheduled to be completed in phases beginning in early 2008
includes 12 new operating rooms for a total of 27. For additional information,
you may visit our website at
www.luhs.org.
Interested applicants should send
a copy of their CV and a list of three individuals who can provide references by
mail to: Steven DeJong, M.D., Vice Chair for Clinical Affairs, Department of
Surgery, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL
60153 or via e-mail at
sdejong@lumc.edu . Loyola University Medical Center is an equal opportunity,
affirmative action employer.
Resident Corner
How To Be A Doctor
by Dr. Christine Gresik
When I began my surgical
internship, I was under the impression that I would become a bona fide
operative surgeon by the end of the year. However, while I am happy to
report that I have had several opportunities to work on my “knot tying”
skills inside of the OR this year, I am also aware of the vast amount of
knowledge and surgical skills I am lacking. It’s a good thing it’s a
five-year program!
As I reflect on this past year,
(which has gone by remarkably quickly!) it fascinates me to realize how I have
grown into my role as a physician. My main objectives at the beginning of this
year were to get through call without any tragedies, expedite discharges, making
sure that all TPN orders were in by noon and befriending all of the nurses in
PAT. Despite seeming like mediocre tasks, I now realize that in the midst of
the entire scurry of those first few months I actually learned something! I have
gained the confidence and knowledge to diagnose critical illnesses, treat
complex medical conditions, analyze lab data and develop strategies to prevent
complications. At the same time, I realize that I have learned the majority of
this information outside of the operating room…so am I learning the correct
items pertinent to my future profession?
I recently had a discussion with
one of the second year residents about my frustrations of spending so much time
outside of the OR. I was assured that my feelings were normal and that no one
walks away from internship feeling like a well-trained “surgeon.” Rather, the
main objective of internship is to learn how to be a “doctor.” Looking back at
those main objectives I had at the beginning of the year and thinking about what
is important to me, I now realize that is exactly what has happened to my entire
class. It’s refreshing to answer a page with confidence, possessing a deeper
understanding of certain disease processes, and to have the capability of
developing a plan for the patient based not only on medical knowledge, but also
experience. I also find myself becoming more of a teacher to the medical
students rather than a peer and cannot wait to share my experience as an intern
to our incoming class of interns this summer.
I guess that knowledge gained is
in the eye of the beholder. I may not know how to perfectly manage a perforated
diverticulum in the operating room, but I am confident I could still be a
wonderful doctor for that patient, providing many of their needs outside of the
OR. Surgeons in general are much more than operating machines. That is one of
the key lessons to learn as a surgical intern. If I take advantage of the
experience I will have during the remainder of this year and focus on learning
the pathology, biochemistry, pharmacology and microbiology of surgical
processes…maybe next year I’ll be handed the scalpel a little more often!
Teaching and Learning
As surgeons, we are expected to be
the captain of the ship, and are frequently constructing the clinical options
for patients during their most vulnerable times. Obviously, this leads to many
stressful discussions in which appropriate clinical acumen and interpersonal
skills are critical to an optimal outcome. Unfortunately, many of us do not
learn how to conduct these conversations until after completing residency and
even then through the process of trial and error. Understanding the
applicability of these skills to surgical residents, our Department of Surgery
in partnership with the Surgical Service of Edward J. Hines Jr. VA Hospital
(Drs. Temeck, Joehl, Sachdeva, Littooy) and the American College of Surgeons,
Division of Education (Drs. Sachdeva, Risucci, and Patrice Blair) developed a
structured education module that challenges residents’ technical and
interpersonal skills after an adverse intraoperative event.
This module exposes second year
residents to an operating room scenario which includes an adverse event, and
this is followed by disclosure of this event to a standardized actor, who
portrays the patient’s spouse. Technical and interpersonal skill sets are
evaluated by residents, the standardized actor, and expert faculty. Feedback
is then grouped and returned to the participating residents. We have shown this
module to be challenging and realistic for residents (Am J Surg
2005;190(5):687-90). Through such innovative approaches, we hope to improve our
residents’ comfort and performance in difficult situations and move the
acquisition of these important skills into the resident years. This year our
nine PGY-2 residents participated in this module, and although evaluations are
not complete, overwhelmingly, the residents found the module both challenging
and educational.
We think that this project is a
valuable addition to the variety of “hands on” learning opportunities that our
Department of Surgery provides as adjuncts to our training. It has provided our
department with the opportunity to work with the College on novel approaches to
improving resident education. We aim to use this module and others like it as
educational exercises for our junior resident curriculum on a recurrent basis.
Hand-Sewn Bowel Anastomosis Training
Under the
supervision of Dr. J. Santaniello, the general surgery residents participated in
a daylong course to enhance their skills at performing hand sewn bowel
anastomosis. Many surgical residents have commented that most anastomosis are
now done with staplers and they wanted to be able to practice hand-sewn
techniques in a life-like model outside of the operating room. The day started
with a presentation/lecture which went over the relevant surgical history
pertaining to bowel anastomosis and the various techniques. Dr. Santaniello
gave his input on the techniques he favors. Lunch was provided and the merits
of various techniques were discussed. Finally, the residents went to the pig
lab and were divided into groups with senior residents guiding junior
residents. After all the residents had completed a few anastomosis, other
procedures were done including splenectomy and distal splenorenal shunts. The
day received rave reviews from the residents who participated. We hope to
expand this experience next year to incorporate laparoscopic procedures. Any
alumni who wish to participate in the next event would be welcomed.
GME Committee
Representative
Dr. Luke Brewster has been elected by his fellow surgery
residents to serve as their representative to the institutional Graduate Medical
Education Committee. Effective immediately.
In Their “Spare” Time
It is a well-known fact that trainees within our Department
of Surgery work VERY hard to further their education and provide quality
care to our patients. But just as they are dedicated to their profession, they
are successful, too, in their activities away from work. Below is just a
sampling of the wide variety of activities and interests reported by some of our
residents and fellows:
Knitting, sewing (need to exercise my hand skills in a fun
and artistic way!), reading, traveling, and, of course, the one and only
“working out”, attending movies, exhibitions, all of which come only after
catching up on my sleep!
-
Irene Sheynman, DDS, General Dentistry Residency
Spending time with my high-school sweetheart who happens to
be my husband, taking ski trips together, cooking, knitting and quilting. I am
far more “domestic” than you might think!
-
Melissa Hulvat, MD, General Surgery Resident
Surgery, surgery, and “um”, more surgery – like a good
resident, I don’t do anything but surgery.
-
Jason Smith, MD, General Surgery Resident
Private pilot (single engine planes), triathlons, weight
lifting, beach volleyball, and hanging out with friends.
-
Mark Keldahl, MD, General Surgery Resident
Quilting, baking, adventure racing, and running.
-
Micah Sinclair, MD, General Surgery Resident
I love to see live music, am an avid bicyclist. and enjoy
reading and writing. I LOVE bowling, spending time with friends, and enjoying
good food and spirits now and then.
-
Shawn Obi, DO, General Surgery Resident
Skyscrapers – I love skyscraper architecture and have a
large database where I keep adding photos. My goal is to photograph all 518
skyscrapers (over 500 ft.) in the US. I currently am 82% complete with 428
photos.
Numismatics – “coin collecting” for the layman. I focus
mainly on US coins and hope to complete a type set (one coin of each design made
by the US from 1793 to present).
- Kip
Melstrom, MD, Surgery Research Resident
New Residency and Fellowship
Recruits - July 2007
The Department of Surgery is
pleased to welcome the following individuals to our training programs beginning
in July
|
GENERAL DENTISTRY |
| Bhargava, Sumita |
|
University of California San Francisco School of Dentistry |
| Milos, Michael |
|
Marquette University School of Dentistry |
| Pandya, Mitra |
|
University of Pittsburgh School of Dental Medicine |
| Ramakrishma, Sean |
|
NYU College of Dentistry |
| |
|
ORAL & MAXILLOFACIAL SURGERY |
| Drouin, Chad |
|
Southern Illinois University |
| Salman, James |
|
University of Louisville School of Dentistry |
| |
|
GENERAL SURGERY |
| Baker, Todd |
Categorical |
Loyola |
| Davis, Christopher |
Categorical |
University of Cincinnati |
| Frazier, Jason |
Categorical |
Howard University |
| Gibbs, Jeffrey |
Categorical |
Drexel University |
| Sieber, David |
Categorical |
Loyola |
| Tabone, Lawrence |
Categorical |
Loyola |
| Al-Nouri, Omar |
Preliminary Non-Designated |
Nova Southeastern Osteo. |
| DiMiceli, Mary |
Preliminary Non-Designated |
Georgetown University |
| Doliner, Marina |
Preliminary Non-Designated |
Rosalind Franklin/CMS |
| Ebner, Laura |
Preliminary Non-Designated |
Eastern Virginia Med Schl |
| Geist, Derik |
Preliminary Non-Designated |
Indiana University |
| Guilliot, John |
Preliminary Non-Designated |
LSU - New Orleans |
| Herr, Christine |
Preliminary Non-Designated |
Univ of IL - Chicago |
| Stone, Marielle |
Preliminary Non-Designated |
Jefferson Med College |
| Woodworth, Amanda |
Preliminary Non-Designated |
Albany Med College |
| Berger, David |
Preliminary - Designated (GU) |
Univ of Missouri - K.C. |
| Brancato, Sam |
Preliminary - Designated (GU) |
Univ of Missouri - Columbia |
| Rao, Manoj |
Preliminary - Designated (GU) |
St. Louis University |
| Braca, John |
Preliminary - Designated (NS) |
New York Medical College |
| Adusei, Andrew |
Preliminary PGY2 |
Univ of Texas - Southwestern Texas Tech - El Paso Residency |
| Stanley, Edwin |
Preliminary PGY2 |
Madras Med College / India Mayo Clinic Residency |
| |
|
PLASTIC SURGERY |
| Salvino, Michael |
|
Northwestern University General Surgery Residency |
| |
|
SURGICAL CRITICAL CARE |
| Larson, Jennine |
|
Southern Illinois University General Surgery Residency |
| |
|
VASCULAR SURGERY |
| Hershberger, Richard |
|
University of Texas - Southwestern General Surgery Residency |
The Vascular Surgical Fellowship at Loyola University Medical Center was created
in 1978, with the primary objective of providing comprehensive training for the
management of arterial and venous disease.
Please click on the link
to view the 4 minute video about the program.
http://msvideo.luhs.org/luhs/pvsurgery.wmv
Research
Faculty Member’s Studies on Alcohol-Induced Bone Loss
Advance Orthopaedic Research
A high percentage of college students and young adults
frequently binge drink, a pattern of rapid alcohol consumption that poses both
short- and long-term health risks. Investigators in Loyola’s Alcohol Research
Program have made several important new discoveries in the past few years about
the effects of binge alcohol exposure on bone.
“We have a whole population of
young people who are damaging their skeletons and not realizing it,” said John
Callaci, Ph.D.,
assistant professor in Loyola’s Department of Orthopaedic
Surgery and Rehabilitation and a member of the Alcohol Research Program.
In 2002 Callaci was the first
postdoctoral research fellow to be funded by the Department of Surgery’s T32
training grant from the National Institutes of Health. He worked in the lab of
Frederick Wezeman, Ph.D., professor in the Department of Orthopaedic Surgery and
associate dean of the Graduate School at the medical center. Now Callaci has his
own lab and is studying the effects of binge alcohol exposure on skeletal
biology in the young and the elderly.
Because young binge drinkers
consume large amounts of alcohol when they are building peak bone mass, they are
at increased risk for osteoporosis and fractures. Binge drinking is commonly
defined as consumption in a two-hour period of five or more alcoholic drinks for
males and four or more drinks for females.
New findings
Loyola has one of the leading
research programs in the field of alcohol-induced osteoporosis, according to
Wezeman. In the past, researchers thought that binge drinking damaged only bone
formation. However, Callaci, Wezeman and other Loyola investigators showed that
bone resorption also is affected. And, contrary to what other researchers had
found in 1997, they discovered that this alcohol-induced bone loss could be
reversed, using bisphosphonates, compounds that inhibit bone resporption.
Now Callaci is trying to find
the mechanisms of how binge drinking damages bone. He is performing bone mineral
density and bone compressive strength analyses on alcohol-fed rats. The rats are
given a high dose of alcohol three days a week, to mimic the pattern of a
weekend binge drinker. After just four weeks of alcohol exposure, he saw a 25
percent decrease in bone strength and bone mass.
“The damage is at least as
significant as that in rats given alcohol every day,” Callaci said.
At the gene level
In a model of acute alcohol
exposure, standard bone tests did not show signs of bone damage in the rats one
week after alcohol exposure. However, gene array expression profiling of bone
did show differences that Callaci believes correlate with early bone damage.
This new technology, which integrates molecular genetics and computer
science, is a way to map what is going on at the gene level. It allows detection
of a pattern of change, or “signature,” in RNA samples. Callaci hopes to extract
a gene array signature from bone and determine whether they can predict bone
loss based on the signature.
“I think ultimately we’ll be
able to see early molecular signs of alcohol-induced bone damage before they are
seen clinically,” he said.
Ultimately, his research may
reveal an overlap between damage caused by alcohol and early signs of osteopenia
and osteoporosis. “Possibly the biomarkers we are trying to discover may have
utility in other areas,” Callaci said.
“If Callaci is able to find
early signs of bone damage, doctors would be able to intervene with preventive
treatment,” said Elizabeth Kovacs, Ph.D., professor of surgery and director of
the Alcohol Research Program. “His novel studies,” she said, “have won the
attention of the National Institute on Alcohol Abuse and Alcoholism.”
The NIAAA is funding a four-year
grant for Callaci to find new biomarkers of alcohol-related damage on tissues
and bone. He is working on the project with Wezeman and lab technician Ryan
Himes.
“Dr. Callaci’s studies,” Wezeman
said, “are a welcome advance in orthopaedic research.”
Innovative Studies Find Possible Key to Better Wound Healing
Loyola basic science researchers
studying burn injury have uncovered findings that may lead to the development of
a way to improve wound healing. And a Loyola surgical resident is helping make
it happen.
Douglas E. Faunce, Ph.D.,
assistant professor of surgery, has been studying the role that natural killer T
cells (NKT cells) play in the immune suppression that occurs after burn injury.
He and his laboratory technicians, Julia Tulley, M.S., and Jessica Remus, M.S.,
compared genetically engineered knockout mice that lack NKT cells against normal
wild-type mice and observed considerably improved wound healing in NKT
cell-deficient mice. Dave Schneider, M.D., currently a third-year surgical
resident, saw the results of their experiment.
“The burn wound in the mice
without NKT cells looked dramatically different,” Schneider said. “It definitely
healed better than in the other type of mice.”
What Schneider saw was so
important that he said, “I knew I had to work with Dr. Faunce. It
was worth
spending the time in research.”
Now Schneider is performing a
two-year research fellowship in Faunce’s lab at the Burn and Shock Trauma
Institute of Loyola University. His fellowship is funded by the Department of
Surgery’s T32 institutional research training grant from the National Institutes
of Health. Loyola is one of only 22 institutions in the country, and the only
one in Illinois, that received the NIH postdoctoral grant for training and
laboratory experience in research related to trauma and burn science.
Schneider and Faunce were able to
replicate the wound healing results in mice with an excisional wound, a better
model for wound healing than burns. “Wounds in animals that lack NKT cells have
30 to 50 percent faster healing,” he said.
Unique focus
Faunce called the research that
Schneider has continued “a potential revolutionary advance in the field of wound
repair.”
“He is studying a mechanism that
dramatically accelerates wound closure without causing hypertrophic scars,”
Faunce said. “The unique thing about Dave’s research is that he is the first to
approach manipulating a specific cell type rather than a single growth factor or
inflammatory mechanism. He may be changing multiple factors, because he is
creating a different microenvironment within the wound. That’s probably why his
approach is so successful.”
Schneider
and Faunce hypothesize that, under normal circumstances, NKT cells limit the
speed and extent of the local inflammatory response, likely during the initial
phase of wound healing.
“These cells seem to be the brakes
on early inflammation,” Schneider explained. “We have measured differences in
wound healing as early as 12 hours in mice.”
Schneider is studying ways to
modify NKT cells, by blocking their activation. In both mice and humans, NKT
cells are activated by the CD1d antigen-presenting molecule, the only immune
cell to do so.
Clinical implications
This molecular pathway in mice
will, Schneider believes, translate to patients. His work holds promise for the
many patients with delayed or altered wound healing, such as those with diabetes
or vascular disease, elderly patients and smokers. Burn patients also could
benefit, he said.
Faunce has developed an approach
to modify NKT cell function, and he and Schneider plan to begin preclinical
studies in a year. According to Faunce, the NIH training grant allows Schneider
and other research fellows the hands-on experience to see how the therapies they
use at the bedside are developed. “It’s not something you can get from a
textbook,” he said.
Schneider is one of two Loyola
surgical residents who have trauma and burn research fellowships through the NIH
training grant from the National Institute of General Medical Sciences. The
other trainee is Gerard Abood, M.D., PGY-4 surgical resident. In addition, Kurt
Melstrom, M.D., PGY-4, and Areck Ucuzian, M.D., PGY-3, are also conducting
research fellowships through the Department of Surgery.
Satellite Symposium
The Burn & Shock Trauma Institute is a proud supporter of
“Alcohol and Trauma 2007,” the Satellite Symposium of the 30th
Annual Meeting of the Shock Society. It will be held in Baltimore, MD on
Friday, June 8 and Saturday, June 9. Elizabeth J. Kovacs, Ph.D. (Combined
insult of ethanol and burn injury trigger local and systemic inflammatory
responses), and Carol R. Schermer, M.D., M.P.H. (The nuts
and bolts of brief alcohol interventions for trauma patients) are
among the invited speakers.
For information about the meeting, please contact Elizabeth
J. Kovacs, Ph.D., (708) 327-2477 email: ekovacs@lumc.edu.
Lindberg Award
This year’s annual American Burn Association (ABA)
Meeting was held in San Diego, California from March 21st – 23rd,
2007. During the Presidential Address and Award Ceremony, Department of Surgery
research assistant professor, Kuzhali Muthumalaiappan, Ph.D. was presented with
the Robert B. Lindberg Award.
Robert B. Lindberg, Ph.D. (1914-1982) was an
internationally recognized microbiologist. His research career spanned more than
half a century. This award, named in his honor, is presented at the annual ABA
Meeting for the best scientific paper submitted by a non-physician. Dr. Kuzhali
Muthumalaiappan, known to her friends and colleagues as Dr. Kay Muthu, received
the award for her paper entitled “Perturbed Bone
Marrow Monocyte Development Following Burn Injury And Sepsis Promote
Hypo-Responsive Monocytes.”
Dr. Muthu joined
the Burn and Shock Trauma Institute as a full-time faculty member in January
2006. Prior to her appointment, she worked as a research associate in the
Institute since 2001 where Ravi Shankar, Ph.D. served as her mentor.
Interestingly enough, Dr. Shankar was chosen as the recipient of the Robert B.
Lindberg Award at the previous ABA Meeting in 2006 for his research paper
entitled “Gene Transfer Treatment for Multi-Drug Resistant Acinetobacter
Baumannii.”
Congratulations to
both Dr. Muthu and Dr. Shankar for shining the spotlight on us for two year’s in
a row!
Publications/Presentations/Awards
Publications
Endorf, F.W. and Gamelli, R.L.: Inhalation Injury,
Pulmonary Perturbations And Fluid Resuscitation. J Burn Care Res. 2007 Jan-Feb;
28(1): 80-3.
Hurtuk, M.G., Shoup, M., Aranha, G.V.,
Devata, S., Brown, K.M., Oshima, K., and Pickleman, J.: Should All
Patients With Duodenal Adenocarcinoma Be Considered For Aggressive Surgical
Resection. Am J Surg 2007; 193: 319-325
Leon, L.R. Jr, Villar, H., Leon, C., Psalms, S., and
Aranha, G.: The Journey Of A Foreign-Trained Physician To A United
States Residency. J Am Coll Surg 2007; 204: 486-494
Plackett, T.P., Colantoni, A., Heinrich, S.A., Messingham,
K.A., Gamelli, R.L., and Kovacs, E.J.: The Early Acute Phase
Response After Burn Injury In Mice. J Burn Care Res. 2007 Jan-Feb;
28(1):167-172.
Shankar, R., He, L.K., Szilagyi, A., Muthu, K.,
Gamelli, R.L., Filutowicz, M., Wendt, J.L., Suzuki, H., and Dominguez, M.:
A Novel Antibacterial Gene Transfer Treatment For Multidrug-Resistant
Acinetobacter Baumannii-Induced Burn Sepsis. J Burn Care Res. 2007
January/February; 28 (1):6-12.
Books
Granick, M.S. and Gamelli, R.L.: Surgical Wound
Healing And Management. Blackwell Publishing, February 2007.
Book Chapters
Gamelli, R.L.: Surgical Management of Necrotizing
Fasciitis. Surgical Wound Healing and Management. Taylor and Francis
Group LLC, February 2007.
Pruitt, B.A. and Gamelli, R.L.: Burns. Acute
Care Surgery: Principles and Practice. Britt, L.D., Turnkey, D.D. and
Feliciano, D.V.: Springer, February 2007.
Commentaries
Gamelli, R.L.: Cost-Utility Analysis Applied To The
Treatment Of Burn Patients In A Specialized Center, Archives of Surgery, January
2007.
Presentations
Aranha, G.:
University of Omaha. Complications of Pancreaticoduodenectomy. Visiting
Professor. March 21, 2007. Omaha, Nebraska.
Brems, J.J: Presented “Indicators for Liver
Transplantation” at the Liver Disease Symposium sponsored by the American Liver
Foundation in Chicago.
Brems, J.J: Invited to present at Grand Rounds at
the University of Illinois. “Transplantation and Hepatitis C.”
Gamelli, R.L.: Presentations on “Funding Clinical
Trials”, “Process and Benefits of Burn Center Verification” and participated in
a symposium on burn care at the American Burn Association Annual Meeting in San
Diego.
Gamelli, R.L.: Moderated a correlative session on
“Critical Illness-Critical Science.” American Burn Association Annual Meeting in
San Diego.
Shoup, M.C.: Moderated a poster session on
“Outcomes in Surgical Oncology” at the Society of University Surgeons in
Phoenix, Arizona.
Abstracts
Bennett, B.K., Farrell, R.T., and Gamelli, R.L.:
Financial Barriers to Inpatient Post Acute Burn Care. Abstract presented at the
39th Annual American Burn Association Meeting 2007.
Farrell, R.T., Aleem, R., and Gamelli, R.L.: The
Relationship of Body Mass Index and Functional Outcomes in Patients with Acute
Burns. Abstract presented at the 39th Annual American Burn
Association Meeting 2007.
Farrell, R.T., Bennett, B.K., Gamelli, R.L., and
Mitchell, N.: Impact of Social Support on Discharge Disposition and Functional
Outcomes in Patients with Acute Burns. Abstract presented at the 39th
Annual American Burn Association Meeting 207.
Gosain, A., Muthu, K., Gamelli, R.L., and DiPietro,
L.A.: Norepinephrine Suppresses Wound Macrophage Phagocytic Efficiency via Camp
and PKA. Abstract presented at the 2nd Annual Academic Surgical
Congress 2007.
Mosier, M.J., Gamelli, R.L., Halerz, M.M., and
Silver, G.M.: Microbial Contamination in Burn Patients Undergoing Urgent
Intubation as Part of their Early Airway Management. Abstract presented at the
39th Annual American Burn Association Meeting 2007.
Muthu, K., He, L.K., Melstrom, K., Szilagy, A., Gamelli.
R.L., and Shankar, R.: Perturbed Bone Marrow Monocyte Development Following
Burn Injury and Sepsis promote Hypo-Responsive Monocytes. Abstract presented at
the 39th Annual American Burn Association Meeting 2007.
Pham, T.N., Klein, M.B., Gibran, N.S., Hunt, J.L.,
Gamell, R.L., Silver, G.M., Tompkins, R.G., and Herndon, D.N.: Influence of
Early Beta-Blocker and Oxandrolone on Adult Outcomes in a Multicenter Clinical
Study. Abstract presented at the 39th Annual American Burn
Association Meeting 2007.
Grants & Funding
Shoup, M.C.: Received $30,000 in funding from
Riviera Country Club for research in evaluating T cells and their regulation in
patients with metastatic pancreatic cancer.
Shoup, M.C.: Opened a single institution,
investigator initiated trial entitled “A pilot study of dendritic cell injection
following chemoradiation for locally advanced pancreatic cancer.” The first
patient has completed the study and is doing well without progression of
disease.
Meetings
Aulivola, B.: Served on the program committee for
the Winter meeting of the Peripheral Vascular Surgery Society held in Steamboat
Springs, Colorado.
Shoup, M.C.: Inducted as a new member into the
Society of University Surgeons and was named the Loyola representative to the
society. She also has served as the Loyola Representative for the AAMC course
“Enhancing Team Effectiveness.”
Former Faculty News
Former Faculty Receives New Appointment
Dr. Kimberly
A. Davis has been appointed Vice Chairman for Clinical Affairs for the
Department of Surgery at Yale School of Medicine, New Haven, Connecticut,
effective February 1, 2007.
Dr. Davis moved to Connecticut in
March 2006, after eight years with the Department of Surgery, where she served
as the Section Chief of Surgical Critical Care, the Medical Director of the
Surgical Intensive Care Unit, and the Program Director of the Surgical Critical
Care Fellowship.
As the Vice Chairman for Clinical
Affairs, Dr. Davis will serve as a single contact point for all clinical issues
for the Department of Surgery, including those crossing multiple departmental,
sectional and service lines. In addition to this new appointment, Dr. Davis,
Associate Professor of Surgery, is the Chief of the Section of Trauma, Surgical
Critical, and Surgical Emergencies.
Alumni News
We are always happy to hear what is going on in
the lives of our alumni. The following came to us via email. If you would
like your story to appear in future issues of our Newsletter, please feel free
contact us at surgnews@lumc.edu to share
your life “after” Loyola.
Peter Deveaux, M.D., FACS, Graduated 1999:
“I am a Lieutenant Colonel in the Army stationed at Fort Bragg, North
Carolina, where I am staff General Surgeon; Chief, Section of Colorectal
Surgery; and Assistant General Surgery Residency Program Director. I have
deployed twice to Afghanistan and will be deployed to another warm country
this summer or fall.”
“I am married to Lynn, and we have 4 beautiful
boys: … They are the best people in the world. I passed my boards in
Colorectal Surgery this year and am focusing on trying to get a residency
program in surgery started here at Bragg patterned after the program at Loyola.
I feel fortunate every day that I trained at Loyola.”
Staff Corner
MAGIS
The MAGIS award is
presented quarterly to employees who demonstrate exceptional MAGIS behavior –
Respect – Concern – Care – Cooperation. Each quarter, the MAGIS coordinator and
the nominations sub-committee review all nominations and recommend nominees to
the MAGIS Task Force for their final selection of five recipients for the
award. Angela Harris, Clerkship Coordinator of the Department of Surgery Office
of Education, was chosen as one of the March, 2007 MAGIS Award Recipients.
Education Coordinator, Kimberly
Echert’s, nomination read:
Angela Harris. With a rescheduled suture class scheduled for students
on a Monday, Angela came into the department late on Sunday night
to check that the frozen pigs feet were appropriately thawed. They
were not. She loaded them onto a cart, took them to her home at midnight,
lugged the 40-lb. bag up three flights of stairs to her apartment, and
proceeded to thaw them in her bathtub. She then brought them back in on
Monday
and
managed to set up for the course accordingly.
These efforts are all a result of her having to move this course from Hines
to SSOM due to scheduling conflicts, which is saving our Department
approximately $1200 per year in the process. This is just one wonderful example
of Angela's dedication to her work, to the Department and to our student
programs.”
Angela was taken by surprise when John M. Lee, M.D.,
Ph.D., Dean of the Stritch School of Medicine presented her with the award in
January, 2007. Angela was also honored at a luncheon at the end of March and
presented with a recognition award package. Her photo and the award
nomination have been posted for the quarter outside of the Hospital Cafeteria.
Angela Harris certainly personifies the MAGIS spirit and qualities and is much
deserving of this honor and recognition.
WALK. RUN.
EMPO WER. – This is the slogan for the Y-ME National Breast Cancer Organization’s
Race which is held each year on Mother’s Day. We here in the Department of
Surgery are very familiar with this phrase. That’s because for the past 5 years
– Mary Martinez, Senior Secretary for the Section of Pediatrics, has coordinated
a team from the Department of Surgery to participate in this important
fundraising event.
Mary is
continuing on this Mother’s Day tradition in 2007 by forming a team for the Y-ME
Race which will be held this Mother’s Day, Sunday, May 13th. The 1
or 3 mile walk will begin at Chicago’s Grant Park at 9:00 am. 
Since 1991, Y-ME’s Mother’s Day Events have raised
more than $26 million to help ensure that no one faces breast cancer alone.
Mary Martinez has been very much a part of the continued success of this
fundraiser. We applaud her efforts in coordinating a team and soliciting
donations to this important cause since 2003.
Anyone
interested in participating in the walk or making a donation for the Loyola
Department of Surgery Team, should contact Mary via e-mail at
mmart7@lumc.edu.
The Last Word
Medical Center
Expansion Update
In December 2005,
construction began on the $103 million medical center expansion. The expansion
is scheduled to be completed in phases beginning in early 2008.
The hospital expansion
will include a new, centrally located two-story hospital lobby when construction
is completed. Other patient comforts will include separate elevators and
corridors for patients and the public.
Construction includes the
development of 176,000 square feet of new space and 60,000 square feet of
renovated existing hospital space.
The new facility will contain:
-
12 new operating rooms for a total of 27 – As all
of our surgeons in our Department well know, more operating rooms will allow
the hospital to meet the increased demand.
-
A new staff lounge, pharmacy and frozen section
laboratory for diagnosing biopsies
-
New pre-operative and recovery areas
-
Comfortable space for families to consult with
physicians
-
Two new medical/surgical units with 64 private
rooms for a total of 298 adult medical/surgical beds
-
Conversion from double to single occupancy of some
hospital rooms – to increase patient and family privacy – for a total of 568
licensed beds
-
An inpatient MRI unit – eliminating the need to
transport hospitalized patients
-
New areas for non-invasive cardiac and peripheral
vascular diagnostics
-
Four new cardiac catheterization laboratories
-
Three new electrophysiology laboratories
-
Comfortable space for families to consult with
physicians
-
64 private hospital rooms – Private rooms will
allow patients more privacy and family members greater comfort in being at the
bedside for extended hours; even overnight.
-
The Center for Heart & Vascular Medicine also will
be renovated as part of the medical center expansion. The center, created in
2004, provides an integrated, multidisciplinary approach to caring for
inpatients and outpatients with vascular and heart disorders. The center will
receive a new reception area, new areas for non-invasive cardiac and
peripheral vascular diagnostics, four new cardiac catheterization laboratories
and three new electrophysiology laboratories with room for one additional
laboratory to accommodate growth.
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