Clodia Osipo, PhD Assistant Professor Department of Pathology Breast Cancer Basic Science Program Cancer Immunology Research Program Cardinal Bernardin Cancer Center (888) LUHS-888

Dr. Clodia Osipo received her Ph.D. in Molecular and Cellular Biochemistry from Loyola University in 2002 while working under Dr. Allen Frankfater. Thereafter, Dr. Osipo did her post-doctoral fellowship at the Robert H. Lurie Comprehensive Cancer Center of the Feinberg School of Medicine at Northwestern University. Dr. V. Craig Jordan, the principal developer of adjuvant tamoxifen therapy for estrogen receptor positive breast cancer, was her mentor. Dr. Osipo’s research under Dr. Jordan focused on investigating the role of HER2/neu, the second member of the epidermal growth factor receptor family, in breast tumors that had acquired resistance to tamoxifen in vivo. During this time, Dr. Osipo has published numerous articles, reviews, and book chapters on tamoxifen and other selective estrogen receptor modulators and downregulators. Dr. Osipo joined Dr. Lucio Miele’s breast cancer program as an Assistant professor in September of 2005.

Dr. Osipo's research focuses on

1. Elucidating the role of the IGF-1 signaling pathway in breast tumors that do and not respond to trastuzumab (Herceptin®).
2. Investigating crosstalk between HER2/neu, IGF-1R, and Notch in breast cancer.
3. Identifying novel therapeutic targets in breast cancer for the development of new treatment modalities.
4. Improving approved therapies for breast cancer by identifying combination approaches.

Publications

View a partial list of Dr. Osipo's publications through the National Library of Medicine's PubMed online database.