Clinical Research at Loyola University Department of Ophthalmology
The goals of the clinical research program at Loyola are to provide both students and residents an appropriate environment to foster critical thinking in the scientific method and to provide experience in the basic elements of hypothesis testing and research design. It is expected that both students and residents will assimilate an appropriate knowledge base required to form an appreciation for the challenges that one may encounter even with the most basic of research endeavors.
Choosing an appropriate research question is paramount in developing appropriate protocols that are both feasible and worthwhile. To this end the department has assembled a research mentoring program that is designed to aid students and residents in selection of projects that are relevant and geared to your specific interests. The Clinical Research Program offers a diverse agenda in all levels of clinical research design and implementation. While topics and can developed to meet specific research interests or needs, many existing protocols are currently underway. Ongoing projects under the direction of Dr. Gaynes are available in both clinical laboratory and clinical visual science. Subspecialty research topics are also available.
Dr. Gaynes is primarily involved in translational research in areas pertaining to ocular imaging, drug development and delivery, ocular and systemic drug safety and toxicity and visual attributes of cortical aging and brain injury.
Active Laboratory Studies:
- Diffraction enhanced imaging of human choroidal melanoma .
- The effect of topical nerve growth factor on electroretinographic activity in the NOD/LtJ murine model of diabetes mellitus.
- Binding characteristics of tamsulosin HCL to synthetic melanin in-vitro.
- Anesthetic properties of a novel reptile derived polypeptide in the rabbit cornea.
- The nano based synthetic mammalian lens.
Active Clinical Programs:
- Conjunctival hemorheology in sickle cell disease.
- Vision, aging and cognitive ability: adaptive and coping strategies.
- A novel computer-based software system to visualize in vivo human lens morphology and based on Scheimpflug photographs.
- Functional correlates of intrinsically photosensitive retinal ganglion cells in Parkinson’s disease.
- Utility of a re-designed ophthalmic drop dispenser in the management of chronic open angle glaucoma.
- Positive predictive value of the occurrence retinal vessel abnormalities in the development of subsequent cardiovascular events.
Questions or concerns regarding any aspect of departmental research may be addressed to either Drs. Bruce Gaynes or Evan Stubbs.