Our faculty are dedicated researchers, working to improve the health of our patients through clinical trials and research studies.
| Developmental Alterations in Cardiac Protein Turnover |
J Akar |
Medtronic |
To study the effect of BEEF in patients with congestive heart failure |
| Calcium Entry and Vascular Smooth Muscle Excitation |
KL Byron
L Cribbs |
NIH/NHLBI |
To identify non-selective cation currents in arterial smooth muscle cells and determine their roles in vasopressin-induced action potential generation. |
| T-Type Ca Channels in Development and Cell Proliferation |
L Cribbs |
NIH/NHLBI |
To understand the role of T-type Ca channels in the cardiovascular system with particular focus on instances where they appear to predominate and have unique functions over high voltage-activated, L-type channels. |
| Altered Mechanotransduction Signaling in Type 2 Diabetes and Diabetic Cardiomyopathy |
A Goodman
L Cribbs |
American Heart Association |
To determine what mechanotransduction signaling molecules are differentially regulated in the heart as a result of diabetes and to look specifically at the regulation of PYK2 in the diabetic milieu |
| Antiplatelet Effect of PAR-1 Inhibitors |
WP Jeske |
Caden Biosciences |
To determine whether a specific series of small molecules modulate platelet-activation response. |
| Novel Heparin Antagonists |
WP Jeske
JM Walenga
J Fareed
D Hoppensteadt
M Bakhos |
PolyMedix |
To create a comparative neutralization profile of unfractionated heparin by PolyMedix's novel site-directed antagonists |
| Beta-Adrenergic Receptor Function in Atrial Myocytes |
SL Lipsius
AM Samarel |
NIH/NHLBI |
To test the hypothesis that the ECM-integrin-cytoskeletal complex remodels beta-adrenergic receptor function in atrial myocytes. |
| Serotonin Therapy for Parkinson's Disease and Neurodegenerative Disorders |
J Martin |
Hines VA Hospital |
To develop and produce adeno-associated virus vector genetic constructs for the purpose of developing a novel model of progressive neuronal degeneration as seen in Parkinson's disease. (subcontract with Hines VA Hospital for which Dr. William Wolf is principal investigator) |
| Human Adult Bone Marrow-Derived Stem Cell Therapy for Recovery from Ischemic Stroke |
J Martin |
Illinois Department of Public Health |
To develop and produce adeno-associated virus vector genetic constructs. (subcontract with Hines VA Hospital for which Dr. Gwendolyn Kartje is principal investigator) |
| Cardioprotection against Endotoxins |
R Mestril |
NIH/NHLBI |
To study the mechanism by which hsp70 protects cardiomyocytes against endotoxin-induced injury. |
| Mechanical Activity and Myocyte Remodeling |
AM Samarel
J Martin |
NIH/NHLBI |
To investigate the role of focal adhesion proteins and costameric components in cardiomyocyte remodeling in response to linear and transverse stretch. (subcontract with the University of Illinois at Chicago, a component of a P01 (Integrated mechanisms of cardiac maladaptation) for which Dr. John Solaro is principal investigator and Dr. Brenda Russell is project leader) |
| T3 Rx During Post-infarction LV Remodeling |
AM Samarel
KK Henderson |
T3 Therapeutics and King Pharmaceuticals |
To develop a post-myocardial infarction model to facilitate study of the use of T3 in the treatment of congestive heart failure. |
| HIT Registry |
JM Walenga
WP Jeske
MM Prechel |
Mitsubishi Pharmaceuticals |
To create and maintain the Loyola Registry of Heparin-Induced Thrombocytopenia (HIT) in Cardiovascular Surgery Patients, the only available database of its kind in existence. |
| PiCT Evaluation |
JM Walenga
D Hoppensteadt |
Pentapharm |
To compare the performance of Pefakit PiCT (Pentapharm) to Heptest (Haemachem). |
| Differentiation of LMWHs |
JM Walenga
WP Jeske
MM Prechel
D Hoppensteadt |
Sanofi-Aventis |
Pharmacologic characterization and differentiation of low molecular weight heparins and heparin-derived oligosaccharides. |
