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Frederick H. Wezeman, Ph.D.
Professor, Orthopaedic Surgery
Joint Professor, Department of Cell
Biology, Neurobiology and Anatomy
Associate Dean, Loyola University Graduate
School, Medical Center Campus
Director, Structure of the Human Body Medical Course |
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B.A., Biology, 1964. Hope College.
M.S., Anatomy, 1967. University of Illinois College of Medicine.
Ph.D., Anatomy, 1969. University of Illinois College of Medicine.
NIH Postdoctoral Fellow, Department of Orthopaedic Surgery
1969-1971, Rush-Presbyterian-St. Luke's Medical Center
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EMAIL |
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Current Interests |
| Alcohol-induced bone disease; osteoporosis; bone
development, growth and repair |
Laboratory Focus |
Research is centered on the effects of chronic alcohol consumption on
skeletal function and the development of osteoporosis. Specifically, our
investigations examine the effects of chronic alcoholism on bone cells,
bone growth and turnover, and the role of bisphosphonates and parathyroid
hormone in alcohol-induced bone disease.
Current studies taking place in the laboratory include a comparative study of
various aminobisphosphonates during chronic alcohol consumption in adolescent, adult male
and female, and ovariectomized (osteoporotic) adult female rats. Other studies focus on
the effects of alcohol on the induction of the osteogenic and adipogenic lineages arising
from bone marrow mesenchymal stem cells in vitro. In
addition, the laboratory is engaged in studies on the effects of chronic alcohol
consumption on articular and epiphyseal cartilage, and histomorphometric analysis of the
microarchitecture of cancellous bone during chronic alcohol consumption.
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Publications |
| Wezeman, F. and Gong, Z.
Adipogenic effect of alcohol on human bone marrow-derived mesenchymal stem
cells. Alcoholism Clin Exp Res 28(7): 1091-1101, 2004 |
Callaci, J.,
Juknelis, D., Patwardhan, A., Sartori M, Frost, N. and Wezeman, F.
The effects of binge alcohol exposure on bone resorption and biomechanical
and structural properties are offset by concurrent bisphosphonate hormone
treatment. Alcoholism Clin Exp Res 28: 182-191, 2004. |
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Gong, Z. and
Wezeman, F. Inhibitory effect of alcohol on osteogenic
differentiation in human bone marrow-derived mesenchymal stem cells.
Alcoholism Clin Exp Res 28: 468-479, 2004 |
- Callaci, J, Juknelis, D, and Wezeman, F. Ovariectomy-induced
bone loss can be accelerated by binge alcohol treatment: effects
compensated by intermittent parathyroid hormone. Osteoporosis Int.
(in press), 2005
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| Callaci, J. et al (F.
Wezeman). Binge Alcohol Treatment Increases Vertebral Bone Loss
Following Ovariectomy: Compensation by Intermittent Parathyroid Hormone.
Alcoholism: Clin Exp Res (in press), April 2006 |
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