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John A. McNulty, Ph.D.
Professor
and Vice-chair
Department of Cell Biology, Neurobiology,
and Anatomy
Director, Core Imaging Facility |
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B.A., Biology, 1968. University of the Pacific.
Ph.D., Biology-Marine Biology, 1976. University of Southern
California
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EMAIL |
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Current Interests |
| Pineal gland, neuroimmodulation, neural transplantation,
neurotrophic factors, computer-aided instruction |
Laboratory Focus |
- Ongoing research in our laboratory includes study of the comparative ultrastructure of
pineal complex and regulation of indole metabolism. The comparative neuroendocrinology of
the pineal complex provides unique opportunities to investigate mechanisms of cellular
transduction in melatonin production over light:dark cycles in both photoreceptive and
non-photoreceptive systems. These studies combine microscopic and biochemical
analytical techniques to characterize structural/functional mechanisms.
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- A second area of research involves interactions of the neuroendocrine and immune systems. This area of investigation is designed to test the
hypothesis that the pineal gland is an important "gateway" for
neuro-immunomodulatory functions. Current studies are focusing on
cellular determinants of pineal-lymphocyte interactions in an avian
model.
Finally, experimental paradigms have been developed to test the effectiveness of
web-based computer-aided instruction in the medical curriculum.
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Publications |
| Tsai, S-Y, K.S. Schluns,
P.T. Le, J.A. McNulty.
TGF-β1 and IL-6 expression in rat pineal gland
is regulated by norepinephrine and interlurkiln-1β. Histol. Histopathol.
16:1135-1141, 2001. |
| Shafer, L.L., J.A. McNulty,
Young M.R.I. Brain derived interleiulin-6 modulates the
functional activities of BV2 microglia.
J. Neuroimmumodulation 10:295-304, 2003. |
| McNulty,
J.A., J. Halama, B.
Espiritu.
Evaluation of computer-aided instruction (CAI) in the medical gross anatomy
curriculum. Clin. Anat. 17: 73-78, 2004. |
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