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Gwendolyn L. Kartje, M.D.,
Ph.D.
Chief, Neurology Service, Hines VA
Professor,
Department of Cell
Biology, Neurobiology & Anatomy |
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B.S., Biology, Northern Illinois University, 1976.
Ph.D., Anatomy, Loyola University, 1984.
M.D., Loyola University Chicago, Stritch School of Medicine, 1988.
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Current Interests |
| Neuronal plasticity and recovery of
function after stroke and spinal cord injury |
Laboratory Focus |
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The overall goal of our research program is to use
translational approaches to improve functional recovery after neural injury
by enhancing neuronal plasticity, i.e. the ability of the intact part of the
brain to take over for the damaged area. This laboratory uses the rodent
focal ischemic model to investigate recovery after stroke, or the
drop-weight method of injury to investigate mechanisms of recovery after
spinal cord injury. A variety of methods to enhance neural plasticity and
repair are tested, i.e. blockade of the major neurite growth inhibitory
protein Nogo-A, pharmacologic methods paired with rehabilitation, and adult
human bone marrow stem cell treatment. Functional outcome is then assessed
using a battery of behavioral tests and outcome is correlated with
anatomical tracing to determine axonal plasticity of spared neuronal
pathways, dendritic plasticity using the golgi-cox method, or
electrophysiological methods to directly stimulate and map new neuronal
connections. |
Publications |
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W. J. Z'Graggen, K. Fouad,
O. Raineteau, G.A.S. Metz, M.E. Schwab and G.L. Kartje, Compensatory
sprouting and electrophysiological re-routing after unilateral pyramidal
tract lesion in neonatal rats, J. Neuroscience, 20: 6561-6569, 2000. |
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C..M. Papadopoulos, S-Y.
Tsai, T. Alsbiei, T.E. O’Brien, M.E. Schwab and G.L. Kartje,
Functional recovery and neuroanatomical plasticity following middle cerebral
artery occlusion and IN-1 antibody treatment in the adult rat, Annals of
Neurology, 51: 433-441, 2002. |
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A. Emerick, E.J. Neafsey,
M.E. Schwab and G.L. Kartje, Functional reorganization of the motor
cortex in adult rats after cortical lesion and treatment with mAb IN-1, J.
Neuroscience, 23: 4826-4830, 2003. |
| A. Emerick and G.L. Kartje,
Behavioral recovery and anatomical plasticity in adult rats after cortical
lesion and treatment with monoclonal antibody IN-1, Behavioral Brain
Research, 152: 315-325, 2004. |
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Book Chapters |
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G.L. Kartje
and M.E. Schwab, Axonal Growth in the Adult Mammalian Nervous System:
Regeneration and Compensatory Plasticity, In: Basic Neurochemistry, 7th
edition, Siegel, G., (ed), Lippincott, 2005. |
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T.M. Markus, S-Y Tsai, M.R. Bollnow, R.G. Farrer, T.E. O'Brien, D.R.
Kindler-Baumann, M. Rudin, C. Wiessner, A.K. Mir, M. E. Schwab and G. L.
Kartje. Recovery and brain reorganization after stroke in adult
and aged rats. Ann Neurol. Dec: 58 (6):950-3, 2005 |
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C. Wiessner,
G.L. Kartje, R. Hillenbrand, A.K. Mir and M.E. Schwab, Anti-Nogo-A
antibody therapy after experimental stroke. Pharmacology of Cerebral
Ischemia, Krieglstein J. Klumpp S., (ed), Medpharm Scientific
Publishers, Stuttgart: 343-54, 2002. |
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