Anthony J. Castro, Ph.D.

Professor

Department of Cell Biology, Neurobiology and Anatomy

Director, Medical Neuroscience Course

& Graduate Neuroplasticity Course

EMAIL

Current Interests

Laboratory Focus

Long-term research interests have involved the study of neuronal plasticity, particularly of the brain-damaged newborn. More recent work has focused on the study 

of neuronal transplants. Using anatomical and electrophysiological methods, we have demonstrated the ability of fetal  neocortical grafts to reconstruct neuronal connections damaged by cortical aspiration lesions in the newborn rat. Continuing work involves application of the neuronal grafting methods to lesion models that are clinically more relevant, i.e., perinatal hypoxia-ischemia and adult stroke. This current focus was adapted in recognizing that interruption of the blood supply to the brain represents one of the leading causes of death and permanent disability in both the newborn and the adult.

 

In addition to potential clinical relevance, experiments involving neuronal grafting methods are equally important in providing basic information concerning neuronal development and repair. Accordingly, we have used the transplantation technique to study the bloodbrain barrier, estrogen receptor density and neurotransmitter levels in developing neocortex. Based on our observations that neocortical grafts can rescue neurons that are secondarily threatened by brain injury, we are also examining trophic actions exerted by developing neural tissue. Related to this work, other experiments concern the study of mechanisms or factors that can promote the growth and neural connectivity of the transplants.

Publications

of fetal neocortical transplants on lesion-induced cerebral cortex plasticity. Cell Transplant. 5: 279-286, 1996.

Acarin, L., B. González, B. Castellano and A.J. Castro   Microglial response to N-methyl -D-aspartate (NMDA) mediated excitotoxicity in the immature rat brain. 

J. Comp. Neurol. 367: 361-374, 1996.