Hicks'
Group
Chindo
Hicks, PhD, Assistant Professor
Principle Investigator
Research
mission:
Improvement
of human health through scientific discovery and translational research
Research
interests:
We are interested in
developing and applying bioinformatics and computational systems
biology tools along with genomics approaches to understand the genetic
and genomic basis of common human diseases focusing on cancer and
neurological diseases especially autism.
Research in our laboratory focuses on three major projects:
Gene
function and regulation: Our research on this project focuses
on alternative splicing and its role on gene expression, function
and regulation in cancer and neurological diseases. We are taking
an integrative genomics approach that make use of gene expression
microarray and protein data to model and understand the role of
alternative splicing on protein-protein and its contribution to
phenotypic diversity.
Integrative
bioinformatics and genomics: Our research on this project
focuses on building models of the transcriptional networks involved
in cancer and neurological diseases. We are taking an integrated
approach that makes use of gene expression microarrays and high
throughput genotype data (SNPs) from association studies to infer
causal association between gene expression and common diseases,
and mapping determinants of gene expression, focusing on cancer
and neurological diseases especially autism.
Bioinformatics
solutions for translational research:
Our research on this project focuses on using an integrative bioinformatics
approach to correlate genomic information with clinical information
in cancer, neurological and other common diseases. Our goal is to
facilitate the process from bench to bedside by translating knowledge
of genomic information into better therapies and disease prevention.
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